Evaluation of Simultaneous Dual-radioisotope SPECT Imaging Using 18F-fluorodeoxyglucose and 99mTc-tetrofosmin
نویسندگان
چکیده مقاله:
Objective(s): Use of a positron emission tomography (PET)/single-photonemission computed tomography (SPECT) system facilitates the simultaneousacquisition of images with fluorine-18 fluorodeoxyglucose (18F-FDG) andtechnetium (99mTc)-tetrofosmin. However, 18F has a short half-life, and 511keV Compton-scattered photons are detected in the 99mTc energy window.Therefore, in this study, we aimed to investigate the consequences of thesefacts.Methods: The crosstalk correction for images in the 99mTc energy windowinvolved the dual energy window (DEW) subtraction method. In phantomstudies, changes in the count of uniform parts in a phantom (due to attenuationfrom decay), signal detectability in the hot-rod part of the phantom, and thedefect contrast ratio in a cardiac phantom were examined.Results: For 18F-FDG in the step-and-shoot mode, nearly a 9% difference wasobserved in the count of projection data between the start and end positionsof acquisition in the uniform part of the phantom. Based on the findings,the detectability of 12 mm hot rods was relatively poor. In the continuousacquisition mode, the count difference was corrected, and detectability of thehot rods was improved. The crosstalk from 18F to the 99mTc energy windowwas approximately 13%. In the cardiac phantom, the defect contrast in 99mTcimages from simultaneous dual-radionuclide acquisition was improved byapproximately 9% after DEW correction; the contrast after correction wassimilar to acquisition with 99mTc alone.Conclusion: Based on the findings, the continuous mode is useful for 18F-FDGacquisition, and DEW crosstalk correction is necessary for 99mTc-tetrofosminimaging.
منابع مشابه
evaluation of simultaneous dual-radioisotope spect imaging using 18f-fluorodeoxyglucose and 99mtc-tetrofosmin
objective(s): use of a positron emission tomography (pet)/single-photonemission computed tomography (spect) system facilitates the simultaneousacquisition of images with fluorine-18 fluorodeoxyglucose (18f-fdg) andtechnetium (99mtc)-tetrofosmin. however, 18f has a short half-life, and 511kev compton-scattered photons are detected in the 99mtc energy window.therefore, in this study, we aimed to ...
متن کاملDual radioisotopes simultaneous SPECT of 99mTc-tetrofosmin and 123I-BMIPP using a semiconductor detector.
Objective(s): The energy resolution of a cadmium-zinc-telluride (CZT) solid-state semiconductor detector is about 5%, and is superior to the resolution of the conventional Anger type detector which is 10%. Also, the window width of the high-energy part and of the low-energy part of a photo peak window can be changed separately. In this study, we used a semiconductor detector and examined the ef...
متن کاملdual radioisotopes simultaneous spect of 99mtc-tetrofosmin and 123i-bmipp using a semiconductor detector.
objective(s): the energy resolution of a cadmium-zinc-telluride (czt) solid-state semiconductor detector is about 5%, and is superior to the resolution of the conventional anger type detector which is 10%. also, the window width of the high-energy part and of the low-energy part of a photo peak window can be changed separately. in this study, we used a semiconductor detector and examined the ef...
متن کاملDual radioisotopes simultaneous SPECT of 99mTc-tetrofosmin and 123I-BMIPP using a semiconductor detector
OBJECTIVES The energy resolution of a cadmium-zinc-telluride (CZT) solid-state semiconductor detector is about 5%, and is superior to the resolution of the conventional Anger type detector which is 10%. Also, the window width of the high-energy part and of the low-energy part of a photo peak window can be changed separately. In this study, we used a semiconductor detector and examined the effec...
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عنوان ژورنال
دوره 4 شماره 2
صفحات 66- 71
تاریخ انتشار 2016-07-01
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